| Main Title |
Alpha-2u-globulin : association with chemically induced renal toxicity and neoplasia in the male rat / |
| Author |
Baetcke, K. P. ;
Hard, G. C. ;
Rodgers, I. S. ;
McGaughy, R. E. ;
Tahan, L. M. ;
Baetcke, Karl P.
|
| Other Authors |
|
| CORP Author |
Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment. |
| Publisher |
U.S. Environmental Protection Agency, |
| Year Published |
1991 |
| Report Number |
EPA/625/3-91/019F; OHEA-F-385; PB92143668 |
| Stock Number |
PB92-143668 |
| OCLC Number |
24842709 |
| Subjects |
Risk assessment ;
Alpha globulins ;
Toxicity ;
Kidney ;
Kidney neoplasms ;
Rats ;
Carcinogens ;
Males ;
Kidney diseases ;
Dose-response relationships ;
Species specificity ;
Alpha 2-microglobulins ;
Kidney disease--Diagnosis ;
Cancer--Diagnosis ;
Environmentally induced diseases
|
| Additional Subjects |
Toxicity ;
Kidney ;
Kidney neoplasms ;
Rats ;
Carcinogens ;
Males ;
Risk assessment ;
Kidney diseases ;
Dose-response relationships ;
Species specificity ;
Alpha 2-microglobulins
|
| Internet Access |
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| EHAM |
RA427.3.A456 1991 |
|
Region 1 Library/Boston,MA |
04/29/2016 |
| EJBD |
EPA 625/3-91/019F |
|
Headquarters Library/Washington,DC |
06/01/2001 |
| EJED |
EPA-625/3-91-019F |
|
OCSPP Chemical Library/Washington,DC |
05/30/1992 |
| EKBD |
EPA-625/3-91-019F |
|
Research Triangle Park Library/RTP, NC |
12/20/2002 |
| EKCD |
EPA/625/3-91/019F |
|
CEMM/GEMMD Library/Gulf Breeze,FL |
11/20/2018 |
| ELBD ARCHIVE |
EPA 625-3-91-019F |
Received from HQ |
AWBERC Library/Cincinnati,OH |
10/04/2023 |
| ELBD |
EPA 625-3-91-019F |
|
AWBERC Library/Cincinnati,OH |
12/20/1996 |
| ERAD |
EPA 625/3-91-019F |
|
Region 9 Library/San Francisco,CA |
12/13/1991 |
| ESAD |
EPA 625-3-91-019F |
|
Region 10 Library/Seattle,WA |
05/31/2017 |
| NTIS |
PB92-143668 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
xii, 118 pages |
| Abstract |
The report of a Technical Panel of the U.S. Environmental Protection Agency (EPA) Risk Assessment Forum describes conditions under which the Forum advises EPA risk assessors against using information on certain renal tubule tumors or nephrotoxicity to assess human risk. Risk assessment approaches generally assume that chemicals producing tumors in laboratory animals are a potential cancer hazard to humans. For most chemicals, including many rodent kidney carcinogens, this extrapolation remains appropriate. The scientific studies reviewed by the Technical Panel indicate, however, that some other chemicals induce accumulation of alpha(sub 2u)-globulin, a low-molecular-weight protein, in the male rat kidney. Female rats and other laboratory mammals administered the same chemicals do not accumulate low-molecular-weight protein in the kidney and they do not develop renal tubule tumors. Since humans appear to be more like other laboratory animals than like the male rat, in this special situation, the male rat is not a good model for assessing human risk. |
| Notes |
"Risk Assessment Forum." "EPA/625/3-91/019F." "September 1991." Includes bibliographical references (pages 99-118). |
