Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Influence of Cadmium, Nickel, and Chromium on Primary Immunity in Mice.
Author Graham, J. A. ; Miller, F. J. ; Daniels, M. J. ; Payne, E. A. ; Gardner, D. E. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC
Year Published 1977
Report Number EPA/600/J-78/045;
Stock Number PB-287 137
Additional Subjects Cadmium ; Metals ; Immunity ; Nickel ; Chromium ; Toxicology ; Aerosols ; Inhalation ; Physiological effects ; Mice ; Laboratory animals ; Experimental data ; Concentration(Composition) ; Responses ; Dosage ; Lung ; Exposure ; Nickel oxides ; Reprints ; Humoral immunity ; Hemolytic plaque technique ; Nickel chlorides ; Chromium chlorides ; Cadmium chlorides ; Heavy metals ; Toxic substances
Library Call Number Additional Info Location Last
NTIS  PB-287 137 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 14p
The effects of metals on the primary humoral immune system of mice were investigated using a hemolytic plaque technique to determine the number of specific antibody-producing spleen cells. Inhalation of NiCl2 for 2 hr resulted in a significant negative linear dose response, the lowest effective concentration tested being 250 micrograms of Ni/cu m. Following a 2 hr aerosol exposure to NiCl2, the lung cleared Ni on a first-order kinetics basis. A significant reduction in the number of plaques per 10 to the 6th power cells was also observed with exposure to 190 micrograms of Cd/cu m. Analyses of the data from intra-muscularly exposed mice indicated that concentrations greater than or equal to 3.90 micrograms of Ni/g body weight (as NiSO4) and greater than or equal to 9.25 micrograms of Ni/g body weight (as NiCl2) resulted in significant immunosuppression. Intramuscular treatments with NiO, CdCl2, and CrCl3 had no effect at the concentrations tested.