Record Display for the EPA National Library Catalog


Main Title Pharmacokinetics and Metabolism of Benzo(A)Pyrene and Dimethylbenzanthracene in Rainbow Trout (Salmo Quairdneri) (Final Report) with Cover Letter dated 05/26/1988.
CORP Author New York Univ. Medical Center, NY. ;American Petroleum Inst., Washington, DC.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Publisher 6 May 1988
Year Published 1988
Report Number FYI-AX-0688-0369;
Stock Number OTS-0000369-3
Additional Subjects Pharmacokinetics ; Clinical medicine ; Benzo(a)pyrene ; Dimethylbenzanthracene ; Rainbow trout ;
Library Call Number Additional Info Location Last
NTIS  OTS-0000369-3 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 117p
Rainbow trout were given Benzo(a)pyrene and 7, 12-dimethylbenz(a)-anthracene by gavage. Experiments were designed to determine assimilation, disposition and elimination of these PAH after single doses and multiple doses. Liver, gall bladder and alimentary tissues were extracted to measure parent compounds and metbolites in the tissues. Separate studies were conducted to determine binding of BaP and DMBA metabolites to DNA and the effects of cooking on the concentrations of the PAHs in the edible flesh. Trout assimilated BaP and DMBA rapidly. Initial disposition of the PAHs was to the muscle tissue followed by redistribution within 6 hr such that most of BaP and DMBA was in the liver-gall bladder compartment. Half-times for assimilation and elimination of the compounds were similar, resulting in low levels of accumulation of PAH from a single dose. Most of the BaP and DMBA in the liver-gall bladder compartment 72 hr after administration of a single dose were in the form of metabolites.