Record Display for the EPA National Library Catalog


Main Title Guidelines for carcinogen risk assessment.
CORP Author Environmental Protection Agency, Washington, DC. Risk Assessment Forum.
Publisher Risk Assessment Forum, U.S. Environmental Protection Agency,
Year Published 2005
Report Number EPA/630/P-03-001B; EPA/630/P-03-001F
Stock Number PB2005-105899
OCLC Number 58676256
Subjects Carcinogenicity testing--United States ; Cancer--Risk factors--United States ; Health risk assessment--United States
Additional Subjects United States--Environmental Protection Agency--Risk Assessment Forum ; Cancer ; Guidelines ; Clinical medicine ; Health care ; Oncology ; Information dissemination ; Analyses ; Carcingens ; Environmental Protection Agency (EPA)
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EJBD  EPA 630/P-03-001B Headquarters Library/Washington,DC 03/31/2005
EJER RISK RA427.3.S99 2005 OCSPP Chemical Library/Washington,DC 01/06/2006
ELBD ARCHIVE EPA 630-P-03-001B AWBERC Library/Cincinnati,OH 09/07/2023
ERAD  EPA 630/P-03-001B Region 9 Library/San Francisco,CA 07/29/2005
NTIS  PB2005-105899 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 166 pages ; cm 28
These guidelines revise and replace the U.S. Environmental Protection Agency's (EPA's, or the Agency's) Guidelines for Carcinogen Risk Assessment, published in 51 FR 33992, September 24, 1986 (U.S. EPA, 1986a) and the 1999 interim final guidelines (U.S. EPA, 1999a; see U.S. EPA 2001b). They provide EPA staff with guidance for developing and using risk assessments. They also provide basic information to the public about the Agency's risk assessment methods
EPA/630/P-03-001B. Includes bibliographical references (R-1-R-18).
Contents Notes
Introduction -- Purpose and scope of the guidelines -- Organization and application of the guidelines -- Key features of the Cancer guidelines -- Hazard assessment -- Overview of hazard assessment and characterization -- Analysis of tumor data -- Analysis of other key data -- Mode of action: general considerations and framework for analysis -- Weight of evidence narrative -- Hazard characterization -- Dose-response assessment -- Analysis of dose -- Analysis in the range of observation -- Extrapolation to lower doses -- Extrapolation to different human exposure scenarios -- Extrapolation to susceptible populations and lifestages -- Uncertainty -- Dose-response characterization -- Exposure assessment -- Defining the assessment questions -- Selecting or developing the conceptual and mathematical models -- Collecting data or selecting and evaluating available data -- Exposure characterization -- Risk characterization -- Purpose -- Application -- Presentation of the risk characterization summary -- Content of the risk characterization summary -- Appendix: Major default options -- Appendix B: EPA's guidance for data quality assessment -- References.