Record Display for the EPA National Library Catalog


Main Title Dendritic Cells in Clinics [electronic resource] /
Author Onji, Morikazu.
Other Authors
Author Title of a Work
Fazle Akbar, Sk. Md.
Publisher Springer Japan,
Year Published 2008
Call Number QR180-189.5
ISBN 9784431794660
Subjects Medicine ; Immunology ; Clinical medicine ; Emerging infectious diseases
Internet Access
Description Access URL
Edition 2nd Edition.
Collation online resource.
Due to license restrictions, this resource is available to EPA employees and authorized contractors only
Contents Notes
History of Dendritic Cells -- General Features of Dendritic Cells -- Interactions Between Dendritic Cells and Infectious Agents -- Dendritic Cells and Allergy -- Dendritic Cells and Autoimmunity -- Dendritic Cells in Tumor Immunology -- Dendritic Cells in Transplantation -- Dendritic Cell-based Immune Therapy: Concept, Design, Present Limitations, and Future Projections. Great advances have taken place in basic research and the clinical usefulness of dendritic cells (DCs). It has now been clearly established, for instance, that these cells play a crucial role in immune responses against infectious diseases and cancers. Antigen-presenting DCs are widely distributed in the body and regulate both immunity and immune tolerance. Experimental studies have provided important insights into DCs and how they can be used for treating animal models of various diseases that occur in humans. The role of these cells in pathogenesis and the treatment of human diseases is elaborately set forth in this valuable book. Researchers in the field are optimistic that DCs, already in use for treating patients with cancers, soon can be used therapeutically for patients with chronic infections, autoimmune diseases, and allergic manifestations. This volume provides a working definition of DCs and also explains the phenotypes and functions of DCs so that these can be readily understood not only by clinicians but by immunologists, researchers, and students as well.