| Main Title |
1,2-butylene Oxide: Skin Sensitization Potential in the Guinea Pig with Cover Letter from Bowman Cm, 2020 dow Center to Timm G, Ots dated 01/23/1984. |
| CORP Author |
Dow Chemical Co., Midland, MI. Toxicology Research Lab.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1984 |
| Report Number |
40-8475031 |
| Stock Number |
OTS0507304 |
| Additional Subjects |
Toxicology ;
Health effects ;
Butylene Oxide ;
Primary Dermal Sensitization ;
Mammals ;
Guinea Pigs ;
Dermal ;
Toxic substances ;
Laboratory animals ;
CAS No 106-88-7
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0507304 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
8p |
| Abstract |
Skin sensitization potential of 1,2- butylene oxide was evaluated in 10 male Hartley albino guinea pigs exposed to 0.1 ml of undiluted test compound 4 times over a 7 day period, followed 2 weeks later by a single challenge exposure. Treatment did not produce signs of sensitization in any of the guinea pigs, whereas 9 of 10 guinea pigs exposed to a positive control solution (0.1 ml of DER 331) exhibited a positive response indicative of sensitization. The authors concluded that the test compound was not a potential human skin sensitizer. |
