Record Display for the EPA National Library Catalog

RECORD NUMBER: 33 OF 45

Main Title Probe Study to Determine the Maximum Tolerated Dose of PDMs Fluid in Rabbits, with Cover Letter dated 04/20/1994.
CORP Author Dow Corning Corp., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1994
Report Number OTS-86940001368
Stock Number OTS0558149
Additional Subjects Toxicology ; Health effects ; Toxic substances ; Octamethylcyclotetrasiloxane ; Laboratory animals ; Subchronic toxicity ; Mammals ; Rabbits ; Oral ; Diet ; CAS No 541-02-6 ; CAS No 541-05-9 ; CAS No 556-67-2 ; CAS No 63148-62-9
Holdings
Library Call Number Additional Info Location Last
Modified		 Checkout
Status
NTIS  OTS0558149 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 8p
Abstract
PDMS fluids are used in various dermal applications and Oral ingestions, a previous oral study in rabbits demonstrated signs of weight loss reduction in food consumption and death at the 225 and 1,000 mg/kg dose levels of D4 and 2,000 ag/kg of DOW CORNING 200 Fluid, 350 as. These adverse effects indicated a need for the donages to be lowered to a point where the material would not cause any signs of toxicity to the pregnant female. The present study was designed to evaluate the maximum tolerated dose of these materials.