Record Display for the EPA National Library CatalogRECORD NUMBER: 6 OF 14
|Main Title||Five-day Repeated Dose Inhalation Toxicity Study in Rats of Cumene with Cover Letter.|
|CORP Author||Gulf Oil Exploration and Production Co., Oklahoma City, OK.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.|
|Additional Subjects||Toxicology ; Health effects ; Cumene (98-82-8) ; Subchronic Toxicity ; Mammals ; Rats ; Inhalation ; Toxic substances ; Laboratory animals ; CAS No 98-82-8|
Cumene (CAS No. 98-82-8) was evaluated for subchronic toxicity. The test substance was administered by inhalation to rats (5/sex/group) 6 hours/day for 5 days at concentrations of 0, 2,000, or 5,000 ppm. All rats in the highest exposure group died after 2 days; necropsy revealed congestion of tissues, red fluid filled bladders, and excessive ocular and nasal accumulations. The females of the 2,000 ppm group had hypothermia and a significant weight loss, and all animals in this group had labored respiration and ocular and nasal discharge.