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RECORD NUMBER: 6 OF 14

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Main Title

Five-day Repeated Dose Inhalation Toxicity Study in Rats of Cumene with Cover Letter.

CORP Author

Gulf Oil Exploration and Production Co., Oklahoma City, OK.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.

Year Published

1985

Report Number

878216016

Stock Number

OTS0206783

Additional Subjects

Toxicology ; Health effects ; Cumene (98-82-8) ; Subchronic Toxicity ; Mammals ; Rats ; Inhalation ; Toxic substances ; Laboratory animals ; CAS No 98-82-8

Holdings

Library	Call Number	Additional Info	Location	Last Modified	Checkout Status
NTIS	OTS0206783	Some EPA libraries have a fiche copy filed under the call number shown.		07/26/2022

Collation

29p

Abstract

Cumene (CAS No. 98-82-8) was evaluated for subchronic toxicity. The test substance was administered by inhalation to rats (5/sex/group) 6 hours/day for 5 days at concentrations of 0, 2,000, or 5,000 ppm. All rats in the highest exposure group died after 2 days; necropsy revealed congestion of tissues, red fluid filled bladders, and excessive ocular and nasal accumulations. The females of the 2,000 ppm group had hypothermia and a significant weight loss, and all animals in this group had labored respiration and ocular and nasal discharge.

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