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Main Title Cumene (isopropyl Benzene): Thirteen-week Vapor Inhalation Study in Rats (Final Report) with Attachments and Cover Letter Dated 09/25/1991.
CORP Author Mellon Inst.-Union Carbide Corp., Export, PA. Bushy Run Research Center.; Chemical Manufacturers Association, Washington, DC.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1991
Report Number 86-910001020
Stock Number OTS0530781
Additional Subjects Toxicology ; Health effects ; Cumene (98-82-8) ; Subchronic Toxicity ; Mammals ; Rats ; Inhalation ; Toxic substances ; Laboratory animals ; CAS No 98-82-8
Library Call Number Additional Info Location Last
NTIS  OTS0530781 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 568p
Cumene (CAS No. 98-82-8) was evaluated for subchronic toxicity. The test substance was administered by inhalation to rats (15/sex/group) 6 hours/day, 5 days/week for 13 weeks at concentrations of 0, 50, 100, 500, and 1,200 ppm. No mortalities were observed, and there were no exposure-related cataract formations, neurotoxic responses, body weight changes, or gross pathologic findings. All treated females and the males of the 2 highest exposure groups had swollen periocular tissue. Absolute and relative liver weights were increased in both sexes at 1,200 ppm and in females at 500 ppm. There was an increase in the absolute and relative lung and adrenal gland weights in females of the 1,200 ppm group.