Record Display for the EPA National Library Catalog


Main Title Micronucleus Test of Cumene with Cover Letter.
CORP Author Gulf Oil Exploration and Production Co., Oklahoma City, OK.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1985
Report Number 878216015
Stock Number OTS0206782
Additional Subjects Toxicology ; Health effects ; Cumene (98-82-8) ; Genotoxicity ; Chromosomal Effects ; Mammals ; Mice ; Oral ; Gavage ; Toxic substances ; Laboratory animals ; CAS No 98-82-8
Library Call Number Additional Info Location Last
NTIS  OTS0206782 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 25p
The ability of cumene to induce micronuclei in bone marrow polychromatic erythrocytes of groups of 10 male and 10 female Crl:CDR-1(ICR)BR Swiss mice was evaluated at dose levels of 0.25, 0.50, 1.00 (2 doses), and 1.00 (1 dose, 15 animals) g/kg administered in paraffin oil by gavage once daily for two days using bone smears prepared, half on day 3 and half on day 4, following onset of dosing. Dose levels were based on prelim- inary toxicity studies. No significant (p<=0.05) increase occurred in any cumene dose group relative to controls, although the positive control, admin- istered 75 mg/kg cyclophosphamide intraperitoneally, didshow a difference (p<=0.05).