||Identification of P-tert-butylbenzoic Acid as an Urinary Metabolite of P-tert-butyltoluene, P-tert-butylbenzaldehyde in Rats with Cover Letter dated 09/23/1986 (company Sanitized).
||; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Health effects ;
1-dimethylethyl)benzaldehyde (939-97-9) ;
Pharmaco Kinetics ;
Toxic substances ;
Laboratory animals ;
CAS No 98-51-1 ;
CAS No 939-97-9
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
The excretion of 4-(tert-butyl)benzoic acid (TBB) as an urinary metabolite of 4-(tert-butyl)toluene (TBT) was studied in rats (strain and number of animals not reported) exposed by gavage to dose levels of 0, 25 or 100 mg/kg/day for 5 days. Urine was sampled 24 hr after the last dosing. TBB was identified as a dose-related urinary metabolite of TBT. No TBB was detected in control animals. No 4-(tert-butyl)hippuric acid was detected in any of the animals.