Record Display for the EPA National Library CatalogRECORD NUMBER: 4 OF 4
|Main Title||Toxicity of Fine Chemicals: Preliminary Studies for the Detection of Testicular Changes in Rats with Cover Letter dated 04/25/1986.|
|CORP Author||Shell Oil Co., Houston, TX.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.|
|Additional Subjects||Toxicology ; Health effects ; 1 ; 3-dichloropropane (142-28-9) ; Subchronic Toxicity ; Mammals ; Rats ; Oral ; Gavage ; Reproduction/fertility Effects ; Toxic substances ; Laboratory animals ; CAS No 96-18-4 ; CAS No 96-23-1 ; CAS No 106-95-6 ; CAS No 109-70-6 ; CAS No 142-28-9 ; CAS No 563-47-3 ; CAS No 627-30-5|
3-Bromopropene (CAS No. 106-95-6) was evaluated for subchronic oral toxicity. The test substance was administered by oral gavage to 10 male rats/group for 14 days at 15 mg/kg or 60 mg/kg. Additional groups were exposed to the control vehicles (water or arachis oil) or the positive control, glycerol-a- monochlorohydrin. At 60 mg/kg, signs of compound-related intoxication included excessive salivation in a small number of animals, severe gastric irritation, reduced body weights, and reduced body weight gains. Exposure caused no morphological changes of the reproductive tract and no significant changes in mean testes weights.