||Initial Submission: Acute Toxicity of Phosphorochloridic Acid, Dithyl Ester in Rats, Mice, and Guinea Pigs with Cover Letter dated 08/24/1992.
||Eastman Kodak Co., Rochester, NY.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Health effects ;
Toxic substances ;
Phosphorochloridic acid ;
Diethyl ester ;
Acute toxicity ;
Guinea pigs ;
CAS No 814-49-3
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
The report pertains to phosphorochloridic acid, diethyl ester (synonym: diethylphosphorochloridate) (CAS No. 814-49-3) and is being submitted because of lethality observed in an acute oral toxicity test in mice and severe skin irritation observed in an acute dermal irritation study in guinea pigs. The oral LD, is 100 mg/kg in mice. Mice dosed at 50 mg/kg showed a 65% reduction in cholinesterase. The dermal LD90 in guinea pigs is 0.05-0.1 cc/kg. The report is being identified as a study involving other than human effects (Unit II.B.2.b of CAP Agreement).