Record Display for the EPA National Library Catalog


Main Title Acute Oral Toxicity to Rats of Hexachlorocyclopentadiene with Cover Letter 11/25/1986.
CORP Author Huntingdon Research Centre PLC (England).; Velsicol Chemical Corp., Chicago, IL.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 2000
Report Number 86870000040
Stock Number OTS0513386
Additional Subjects Toxicology ; Health effects ; Hexachlorocyclopentadiene (77-47-4) ; Acute Toxicity ; Mammals ; Rats ; Oral ; Gavage ; Toxic substances ; Laboratory animals ; CAS No 77-47-4
Library Call Number Additional Info Location Last
NTIS  OTS0513386 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 14p
Acute oral toxicity was evaluated in groups of 5 male and 5 female Sprague-Dawley rats administered hexachlorocyclopentadiene in corn oil by gavage at a level of 1.26, 1.60 or 2.00 g/kg. Mortality was observed in 1 male and 2 females in the 1.26 g/kg group, 3 males and 5 females in the 1.60 g/kg group and in all animals in the 2.00 g/kg group. The LD50 was determined to be 1.4 (1.2-1.5) g/kg for males and females combined, 1.5 (1.3-1.7) g/kg for males only and 1.3 (1.0-1.5) g/kg for females only. Clinical observations included piloerection, abnormal posture and gait, lethargy, decreased respiration, ptosis, pallor of the extremities, diarrhea and prostration. Necropsy revealed nothing unusual.