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Main Title Evaluation of Chloroethane Vg and Its Components in the Ames Salmonella/Mammalian Microsome Mutagenicity Assay with Attachments.
CORP Author Dow Chemical Co., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 2000
Report Number 86-890001189
Stock Number OTS0520701
Additional Subjects Toxicology ; Health effects ; Chloroethane (75-52-5) ; Genotoxicity ; Gene Mutations ; Bacteria ; In Vitro ; Toxic substances ; Laboratory animals ; CAS No 71-55-6 ; CAS No 75-52-5 ; CAS No 79-24-3 ; CAS No 115-19-5 ; CAS No 26249-20-7
Library Call Number Additional Info Location Last
NTIS  OTS0520701 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 30p
The mutagenicity of Chlorothene VG solvent and its components (1,1,1-trichloroethane (93.33%), 2,-methyl-3-butyn-2-ol, nitromethane, nitroethane, t-amyl alcohol, and 1,2-butylene oxide) was evaluated in Salmonella tester strains TA98, TA100, TA1535, TA1537, and TA1538, both in the presence and absence of added metabolic activation by Aroclor-induced rat liver S9 fraction. Based on the results of preliminary bacterial toxicity testing, Chlorothene VG was tested at concentrations of 20,664, 41,328, or 165,310 ppm using the dessicator method. Chlorothene VG caused a reproducible positive response in tester strain TA1535, both in the presence and absence of S9 activation. The material did not cause a reproducible positive response in strains TA98, TA1537, or TA1538, either in the presence or absence of activation, although TA100 exhibited a trend toward a positive response.