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Main Title Acute Vapor Inhalation Study in Fischer 344 Rats Using Aerothene Tt with Cover Letter Dated 03/22/1988.
CORP Author Dow Chemical Co., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1988
Report Number 86-880000173
Stock Number OTS0514062
Additional Subjects Toxicology ; Health effects ; 1 ; 1 ; 1-trichloroethane (71-55-6) ; Acute Toxicity ; Mammals ; Rats ; Inhalation ; Toxic substances ; Laboratory animals ; CAS No 71-55-6
Library Call Number Additional Info Location Last
NTIS  OTS0514062 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 34p
Acute inhalation toxicity was evaluated in groups of 5 male and 5 female Fischer 344 rats exposed to Aerothene TT (1,1,1-trichloroethane) at actual concentrations of 15,523, 18,425, or 21,063 ppm for 4 hours. Mortality was observed in 3 females in the 18,425 ppm dose group and all animals in the highest dose group. The LC50 value was reported to be between 18,425 - 21,063 ppm for males and calculated to be 18,000 ppm (16,600-19,400 ppm 95% confidence limits) for females by the moving average method. Clinical observations included lethargy and unresponsiveness. Gross necropsy revealed clear facial soiling and visceral congestion.