Record Display for the EPA National Library Catalog

RECORD NUMBER: 16 OF 22

Main Title Primary Eye Mucosa Irritation Study of Kf-996s (Dodecamethylcyclohexasiloxane) in Rabbits with Cover Letter dated 04/08/94.
CORP Author ; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1994
Report Number 86940001753
Stock Number OTS0572800
Additional Subjects Toxicology ; Health effects ; Dodecamethylcyclohexasiloxane ; Primary Eye Irritation ; Mammals ; Rabbits ; Dermal ; Toxic substances ; Laboratory animals ; CAS No 540-97-6
Holdings
Library Call Number Additional Info Location Last
Modified		 Checkout
Status
NTIS  OTS0572800 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 33p
Abstract
Primary eye mucosa irritation study of KF-996S was conducted in nine Japanese white rabbits. In conclusion, extremely slight hyperemia (score: 0.5 points) in conjunctivae was observed in the instilled side in three animals at one hour after instillation. The total score of the findings was 0.2 points. Because the hyperemia in conjunctivae was not observed on or after 24 hours post instillation, it was thought that the finding was evanescent change. In addition, such slight hyperemia in conjunctivae could appear as a result of the instillation or examination processes. Therefore, the results do not always mean that KF-996S causes irritation. The other findings, namely chemosis and discharge in conjunctivae or changes in cornea and iris were not observed at any time of observation. Additionally, any differences in findings between the washed group and the unwashed group were not observed.