Record Display for the EPA National Library Catalog


Main Title Initial Submission: Acute Toxicity Study with Cyanogen Bromide in Rats (Final Report) with Cover Letter dated 07/24/92.
CORP Author Dow Chemical Co., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1992
Report Number 88-920005758
Stock Number OTS0544541
Additional Subjects Toxicology ; Health effects ; Cyanogen Bromide ; Acute Toxicity ; Mammals ; Rats ; Inhalation ; Toxic substances ; Laboratory animals ; CAS No 506-68-3
Library Call Number Additional Info Location Last
NTIS  OTS0544541 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 10p
Cyanogen bromide (CAS No. 506-68-3) was evaluated for acute inhalation toxicity. The test substance was administered to groups of 10 male and 10 female Sprague Dawley rats. Concentration, duration, and mortality data are as follows: 10 ppm for 6-hours (0/8 M, 0/8 F); 35 ppm for 6-hours (0/8 M, 0/8 F); 45 ppm for 6-hours (8/8 M, 2/8 F); 56 ppm for 6-hours (8/10 M, 10/10 F); and 112 ppm for 2.5-hours (10/10 M, 10/10 F). There were no adverse effects at 10 ppm and transient nasal irritation at 35 ppm. There were no treatment-related lesions at necropsy below 35 ppm. Clinical signs above 35 ppm included moderate to severe respiratory tract irritation, with rats gasping for breath during and after exposure, and severe weight loss with a slow recovery. Necropsy findings revealed severe respiratory tract irritation, congested lungs and liver, and distended stomachs due to mouth breathing. The LC50 was determined to be 39.3 ppm for males and 52.7 ppm for females.