Record Display for the EPA National Library Catalog
RECORD NUMBER: 2 OF 2| Main Title | Ocular Toxicity of Two Glycol Ethers in Fischer 344 Rats Following Subchronic Inhalation Exposures with Cover Letter Dated 09/19/1989. | |||||||||||
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| CORP Author | Union Carbide Corp., Danbury, CT.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. | |||||||||||
| Year Published | 1989 | |||||||||||
| Report Number | 86-890001552 | |||||||||||
| Stock Number | OTS0520681 | |||||||||||
| Additional Subjects | Toxicology ; Health effects ; Propylene Glycol Butoxy Ether (5131-66-8) ; Subchronic Toxicity ; Mammals ; Rats ; Inhalation ; Toxic substances ; Laboratory animals ; CAS No 1569-01-3 ; CAS No 5131-66-8 | |||||||||||
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| Collation | 3p | |||||||||||
| Abstract | Summary data regarding ocular changes following exposure to propylene glycol butoxy ether (PGBE) are compared to those noted in a previous study with propylene glycol monopropyl ether (PGPE). In both studies, F344 rats were exposed 6 hours/day for 9 days over an 11-day period. Reversible keratitis and nonreversible corneal vascularization and splitting were seen with exposure to 503 ppm PGPE, while 600 ppm PGBE caused fibroblastic proliferation, keratitis, and some degeneration in the cornea. No nonreversible lesions observed with PGPE exposure were noted in rats exposed to PGBE. |