Record Display for the EPA National Library CatalogRECORD NUMBER: 2 OF 6
|Main Title||Initial Submission: Teratogenicity Study with Xylene in Mice with Cover Letter dated 07/22/92.|
|CORP Author||Research Triangle Inst., Research Triangle Park, NC.; Rohm and Haas Co., Philadelphia, PA.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.|
|Additional Subjects||Toxicology ; Health effects ; Xylene ; Reproduction/fertility Effects ; Teratogenicity ; Mammals ; Mice ; Toxic substances ; Laboratory animals ; CAS No 1330-20-7|
Xylene (CAS No. 1330-207) was evaluated for developmental effects in mice administered the test substance by gavage at dose levels of 0, 0.6, 1.2, 2.4, 3.0, 3.6 or 4.2 mL/kg/day. There were 15/15 mortalities at 4.2 mL/kg/day and 12/38 at 3.6 mL/kg/day. Maternal body weight gain was reduced in survivors at 3.6 mL/kg/day (p<0.05). The average maternal liver weight was increased at 2.4 and 3.0 mL/kg/day and the average fetal weight was reduced at 2.4 and 3.0 mL/kg/day (p<0.05). The average percent of malformed fetuses was increased at 2.4, 3.0, and 3.6 mL/kg/day (p<0.01). Cleft palate was observed in the 1.2, 2.4, 3.0, and 3.6 mL/kg/day groups.