Record Display for the EPA National Library Catalog

RECORD NUMBER: 8 OF 11

OLS Field Name OLS Field Data
Main Title Oleylamine: L5178y Tk+/- Mouse Lymphoma Mutagenesis Assay with Confirmation (Final Report) with Attachments and Cover Letter Dated 09/29/1989.
CORP Author Microbiological Associates, Bethesda, MD.; Chemical Manufacturers Association, Washington, DC.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 2000
Report Number 40-8984189
Stock Number OTS0525406
Additional Subjects Toxicology ; Health effects ; Oleylamine ; Genotoxicity ; Gene Mutations ; Mammals ; Mice ; In Vitro ; Toxic substances ; Laboratory animals ; CAS No 112-90-3
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NTIS  OTS0525406 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 03/10/2010
Collation 68p
Abstract
Oleylamine was tested for mutagenicity in vitro in L5178Y TK+/- mouse lymphoma cells, both in the presence and absence of Aroclor-induced rat liver S-9 metabolic activation. Based on preliminary determinations of cytotoxicity, the compound was tested in 3 trials without activation at concentrations ranging from 0.13-0.32, 0.13-1.8, and 0.2-1.0 nl/ml culture medium, and in 3 trials with activation, at 1.3- 10.0, 1.3-13, and 1.5-11 nl/ml. Cell survival without activation ranged from 75-99, 3-110, and 6-109%, for the first, second, and third trials, respectively. Cell survival with activation ranged from 6-106, 13-107,and 2-115%,for the first, second, and third trials, respectively. The treatment did not increase the frequency of forward mutations at the thymidine kinase locus, indicating that the test compound was not mutagenic in mouse lymphoma cells under the conditions of this assay.