Record Display for the EPA National Library CatalogRECORD NUMBER: 7 OF 20
|Main Title||In vitro Studies to Evaluate Glycol Ethers as Substrates for Alcohol Dehydrogenase (Sanitized).|
|CORP Author||Dow Chemical Co., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.|
|Additional Subjects||Toxicology ; Health effects ; 1-methoxy-2-propanol (107-98-2) ; Pharmaco Kinetics ; Mammals ; Other Mammals ; In Vitro ; Toxic substances ; Laboratory animals ; CAS No 107-98-2 ; CAS No 109-86-4 ; CAS No 110-80-5 ; CAS No 111-76-2 ; CAS No 111-77-3 ; CAS No 111-90-0 ; CAS No 112-34-5 ; CAS No 34590-94-8|
Metabolism of Dowanol EB (ethylene glycol mono-n-butyl ether) was evaluated in vitro with an equine liver alcohol dehydrogenase assay obtained from the Sigma Chemical Company. The Vmax, Km, and Vmax/Km were 4.06, 1.18X10E-3, and 3.50, respectively. The authors concluded that alcohol dehydrogenase has a high affinity for the test compound, indicating that the test compound is probably metabolized to a significant extent by this enzyme in vivo.