||Actue Dermal Irritation/Corrosion Study of N-Valeraldehyd in Rabbits, with Cover Letter dated 04/05/1999.
||BASF Corp., Mount Olive, NJ.; BASF A.G., Ludwigshafen am Rhein (Germany, F.R.).; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Health effects ;
Primary dermal irritation ;
CAS No 110-62-3
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
The potential of n-Valeraldehyd to cause acute dermal irritation or corrosion was assessed by a single topical application of 0.5 ml of the test substance to the intact skin of 3 White New Zealand rabbits for 4 hours under semiocclusive dressing. The average score (24 to-72 hours) per animal was calculated to be 0.3, 3.0 and 2.0 for erythema and 0.0, 1.0 and 0.3 for edema. The skin findings were not reversible in 1 animal within 14 days after removal of the patches. Symptoms observed and described in the respective observation table in detail together with the average score for irritation indicate an irritant property of the test substance to the skin. Under the test conditions chosen and considering the described findings n-Valeraldehyd gives indication of an irritant property to the skin.