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Main Title Letter from Chem Mfgs Assn to US EPA Regarding Evaluation of Environmental Exposure & Toxicological Testing Results on Cyclohexane with Attachments.
CORP Author Chemical Manufacturers Association, Washington, DC.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 2000
Report Number 40-8623020
Stock Number OTS0527414
Additional Subjects Toxicology ; Health effects ; Cyclohexane ; Reproduction/fertility Effects ; Combined Teratogenicity/reproductive Effects ; Mammals ; Rats ; Inhalation ; Environmental Fate ; Physical/chemical Properties ; Partition Coefficient ; Genotoxicity ; Gene Mutations ; Bacteria ; In Vitro ; Mice ; Chromosomal Effects ; Hamsters ; Subchronic Toxicity ; Toxic substances ; Laboratory animals ; CAS No 108-88-3 ; CAS No 110-82-7
Library Call Number Additional Info Location Last
NTIS  OTS0527414 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 128p
The neurotoxic properties of cyclohexane and n-hexane mixtures were assessed in rats. Animals were exposed for 22 hrs/day for 6 months to 7, 20, or 71 ppm of cyclohexane or cyclohexane in a mixture of C6 hydrocarbons, or to 123, 124, and 128 ppm of n-hexane or hexane mixtures. Neurotoxic effects seen with cyclohexane were consistant with effects from n-hexane or hexane mixtures (axonal swelling and age-related dystrophic axons of the medulla oblongata). No evidence was seen to indicate that cyclohexane, alone, was neurotoxic after 6 months of exposure. Summary reports provided the following information. A mutagenicity assayin Salmonella typhimurium tester strains TA98, TA100, TA1535, TA1535, and TA1538 exposed to concentrations of up to 5200 ug/plate f cyclohexane yielded negative results. Two mouse lymphoma L5178Y forward mutation assays found no increase in forward mutations at the TK locus for activated or non-activated systems. Sister chromatid exchange assays of 5 dose levels of cyclohexane in Chinese hamster ovary cells yielded negative results in both activated and non-activated test systems. An in vivo cytogenetics bone marrow cell assay in rats exposed by inhalation to 96.6 to 1041.6 ppm of cyclohexane for 6 hrs/day on 5 consecutive days yielded negative results. Two-generation reproduction and teratology studies of toluene were conducted in rats exposed by inhalation to concentrations of up to 2000 ppm. No embryotoxicity nor teratogenicity were noted, but at 2000 ppm there was maternal toxicity (not described) and slightly decreased fetal body weight.