Record Display for the EPA National Library Catalog
RECORD NUMBER: 2 OF 8| Main Title | Initial Submission: Chronic Dietary Administration of Maleic Anhydride with Cover Letter dated 09/08/1992. | |||||||||||
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| CORP Author | ITT Research Inst., Lanham, MD.; Union Carbide Corp., Danbury, CT.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. | |||||||||||
| Year Published | 1992 | |||||||||||
| Report Number | 8EHQ-0992-11026 | |||||||||||
| Stock Number | OTS0571063 | |||||||||||
| Additional Subjects | Toxicology ; Health effects ; Toxic substances ; Maleic anhydride ; Chronic toxicity ; Carcinogenicity ; Mammals ; Rats ; Oral ; Diet ; CAS No 108-31-6 | |||||||||||
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| Collation | 24p | |||||||||||
| Abstract | Maleic anhydride was evaluated for toxicologic and/or carcinogenic effects in male and female Fischer 344 rats following dietary administration at levels of 100, 32, and 10 ag/kg/day. A control group received only the basal diet (Wayne Laboratory Meal). The criteria evaluated for compound related effects included: mortality, gross and behavioral signs of toxic or pharmacologic effects, body weights, food and compound consumption, clinical laboratory analysis (hematology, biochemistry, urinalyses), ophthalmology, neurological signs, organ weights and organ/100 g body weight, and gross and microscopic pathology. |