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Main Title Evaluation of Dowanol Pm in the Rat Hepatocyte Unscheduled DNA Synthesis Assay.
CORP Author Dow Chemical Co., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 2000
Report Number 86-890001234
Stock Number OTS0520744
Additional Subjects Toxicology ; Health effects ; 1-methoxy-2-propanol (107-98-2) ; Genotoxicity ; DNA Effects ; Mammals ; Rats ; In Vitro ; Toxic substances ; Laboratory animals ; CAS No 107-98-2
Library Call Number Additional Info Location Last
NTIS  OTS0520744 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 14p
Genotoxicity of 1-methoxy- 2-propanol was evaluated in the rat hepatocyte primary culture/DNA repair assay. The compound was tested at concentrations of 3.16x10E-5, 1x10E-4, 3.16x10E-4, 1x10E-3, 3.16x10E-3, 1x10E-2, 3.16x10E-2, and 1x10E-1 M, in Williams Medium E with 10% fetal calf serum. The negative control and positive control groups were cell cultures exposed to the media only, or the media plus 2- acetylaminofluorene (1x10E-7, 1x10E-6, or 1x10E-5 M) in 1% DMSO, respectively. The treatment was cytotoxic to the cell cultures at 3.16x10E-2 and 1x10E-1 M. The treatment had no effect on the rate of DNA repair, indicating a lack of genotoxicity of 1-methoxy-2- propanol in this cell culture assay.