||Chronic Skin Absorption of Propylene Glycol Methyl Ether (33b) and Dipropylene Glycol Methyl Ether (50b) in Rabbits.
||Dow Chemical Co., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Health effects ;
Dipropylene Glycol Methyl Ether (34590-94-8) ;
Subchronic Toxicity ;
Toxic substances ;
Laboratory animals ;
CAS No 107-98-2 ;
CAS No 34590-94-8
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Propylene glycol methyl ether (PGME) and dipropylene glycol methyl ether (DGME) were applied via occluded cotton pads to clipped, abraded abdominal skin of male rabbits (5/group; strain not reported) 5 times/week for 3 months. Control animals received distilled water via occluded cotton pads. Doses of 7 and 10 cc/kg PGME or 10 cc/kg DGME produced narcosis leading to death. No effects were seen at any dose on hematological parameters nor on gross appearance of organs. An increase in renal weight occurred with 10 cc/kg PGME. No observable effects were seen at doses of 1 or 5 cc/kg of either substance.