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Main Title Initial Submission: Teratological Evaluation of Inhaled Acrylonitril Monomer in Rats with Cover Letter dated 09/01/1992.
CORP Author Du Pont de Nemours (E.I.) and Co., Newark, DE. Haskell Lab. for Toxicology and Industrial Medicine.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1992
Report Number 8EHQ-0892-10275
Stock Number OTS0570857
Additional Subjects Toxicology ; Health effects ; Toxic substances ; Acrylonitril monomer ; Reproduction ; Fertility effects ; Teratogenicity ; Mammals ; Rats ; Inhalation ; CAS No 107-13-1
Library Call Number Additional Info Location Last
NTIS  OTS0570857 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 52p
Pregnant Sprague-Dawley rats were exposed to 0, 40, or 80 ppm of acrylonitrile by inhalation for 6 hrs per day from days 6 through 15 of gestation. Inhalation of 80 ppm, a maternally and embryonally toxic concentration, did not significantly alter the incidence of any single malformation. The incidence of total malformations, when considered col- lectively, was marginally increased (p=0.06) at 80 ppm. Also noted at 80 ppm was a low incidence of the same mal- formations seen in an earlier study in which pregnant rats were given acrylonitrile by gavage. At 40 ppm, significant maternal toxicity was evident, but no signs of embryotoxicity, fetotoxicity, or teratogenicity were seen. In conclusion, findings suggestive of a teratogenic effect were seen in the offspring of pregnant rats inhaling 80 ppm but not 40 ppm of acrylonitrile.