Record Display for the EPA National Library Catalog

RECORD NUMBER: 8 OF 8

Main Title Support: Styrene-104 Week Repeat Dose Inhalation Combined Toxicity/Carcinogenicity Study in Mice with Cover Letter dated 07/22/1998.
CORP Author Huntingdon Life Sceinces, Ltd.; Styrene Information and Research Center, Inc.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1998
Report Number 8EHQ-0798-13707
Stock Number OTS0558579-2
Additional Subjects Toxicology ; Health effects ; Toxic substances ; Chronic toxicity ; Combined chronic toxicity ; Combined chronic carcinogenicity ; Mammals ; Mice ; Inhalation ; CAS No 100-42-5
Holdings
Library Call Number Additional Info Location Last
Modified		 Checkout
Status
NTIS  OTS0558579-2 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 369p
Abstract
This study was performed to assess the chronic toxicity and carcinogenic potential of styrene, administered by whole-body inhalation exposure to CD-1 mice over a period of 2 years. Exposure was carried out for 6 hours a day, 5 days a week at exposure levels of 0, 20, 40, 80 or 160 ppm. The initial group size was 70 mice of each sex, of which 10 mice of each sex were allocated for sacrifice following 52 and 78 weeks of exposure. Due to increased mortality in female control mice terminal sacrifice took place during Week 98. Male mice were sacrificed as scheduled following 104 weeks of exposure. Samples of blood were removed from mice immediately after a typical exposure (Week 74) and analysed for styrene monomer and styrene oxide.