Record Display for the EPA National Library Catalog

RECORD NUMBER: 1 OF 3

Main Title

Evaluation of the potential carcinogenicity of o-toluidine (95-53-4) /

CORP Author

Environmental Monitoring and Services, Inc., Washington, DC. ;Syracuse Research Corp., NY.;Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment.

Publisher

U.S. Environmental Protection Agency, Office of Emergency and Remedial Response ;

Year Published

1988

Report Number

EPA/600/8-91/187; EPA-68-03-3112; EPA-68-03-3182; OHEA-C-073-182

Stock Number

PB93-201200

Subjects

O-Toluidine--Carcinogenicity

Additional Subjects

Toluidines ; Toxicity ; Risk assessment ; Public health ; Exposure ; Hazardous materials ; Neoplasms ; Tolerances(Physiology) ; Carcinogenicity ; Dose-response relationships ; CAS 95-53-4

Holdings

Library	Call Number	Additional Info	Location	Last Modified	Checkout Status
NTIS	PB93-201200	Some EPA libraries have a fiche copy filed under the call number shown.		07/26/2022

Collation

22 pages ; 28 cm

Abstract

The assessment of o-toluidine for potential carcinogenicity is based on data from studies using o-toluidine hydrochloride, since o-toluidine is rapidly and completely converted to the hydrochloride after oral ingestion. Therefore, this profile summarizes the relevant cancer literature on o-toluidine hydrochloride. o-Toluidine is a potential human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment. Evidence on potential carcinogenicity from animal studies is 'Sufficient', and the evidence from human studies is 'Inadequate'. The potentcy factor (F) for o-toluidine is estimated to be 0.069 (mg/kg/day)-1, placing it in potency group 3 according to the CAG's methodology for evaluating potential carcinogens. Combining the weight-of-evidence group and the potency group, o-toluidine is assigned a 'LOW' hazard ranking.

Notes

Cover title. "June 1988." Includes bibliographical references. Microfiche.