The manual summarizes technical information that will assist in identifying and controlling chloropicrin-associated release hazards specific to the South Coast Air Quality Management District (SCAQMD) of southern California. The SCAQMD has been considering a strategy for reducing the risk of a major accidental air release of toxic chemicals. The strategy includes monitoring the storage, handling, and use of certain chemicals and providing guidance to industry and communities. Chloropicrin has an immediately dangerous to life and health (IDLH) concentration of 1 ppm, making it a substantial acute toxic hazard. To reduce the risks associated with an accidental release of chloropicrin, some of the potential causes of accidental releases that apply to processes that use chloropicrin in the SCAQMD must be identified. Examples of potential causes are identified, as are measures that may be taken to reduce the accidental release risk. Such measures include recommendations on: plant design practices; prevention, protection, and mitigation technologies; and operation and maintenance practices. Conceptual costs of possible prevention, protection, and mitigation measures are estimated.