Record Display for the EPA National Library CatalogRECORD NUMBER: 2 OF 6
|Main Title||Evaluation of the potential carcinogenicity of amitrole (61-82-5) /|
|CORP Author||Syracuse Research Corp., NY. ;Environmental Monitoring and Services, Inc., Washington, DC.;Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment.|
|Publisher||U.S. Environmental Protection Agency, Office of Emergency and Remedial Response ;|
|Report Number||EPA/600/8-91/060; EPA-68-03-3112; EPA-68-03-3182; OHEA-C-073-004|
|Subjects||Aromatic compounds--Carcinogenicity ; Amitrole--Carcinogenicity|
|Additional Subjects||Carcinogens ; Toxicity ; Amitrole ; Humans ; Animals ; Dose-response relationships ; Carcinogenicity tests ; CAS 61-82-5|
|Collation||20 pages ; 28 cm|
Amitrole is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment. Evidence on potential carcinogenicity from animal studies is 'sufficient,' and the evidence from human studies is 'inadequate.' The potency factor (F) for amitrole is estimated to be 3.30/(mg/kg/day), placing it in potency group 2 according to the CAG's methodology for evaluating potential carcinogens. Combining the weight-of-evidence group and the potency group, amitrole is assigned a 'MEDIUM' hazard ranking for the purposes of RQ adjustment.
Cover title. "June 1988." Includes bibliographical references. Microfiche.