Record Display for the EPA National Library Catalog


Main Title Carcinogenicity assessment of chlordane and heptachlor/heptachlor epoxide.
Author Cavender, F. L. ; Cook, B. T. ; Page, N. P. ; Cogliano, V. J. ; Koppikar, A. M.
CORP Author United States. Environmental Protection Agency. Carcinogen Assessment Group.
Publisher Carcinogen Assessment Group, Office of Health and Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency,
Year Published 1986
Report Number EPA/600/6-87-004
Stock Number PB87-208757
OCLC Number 16388648
Subjects Chlordan--Carcinogenicity ; Heptachlor--Carcinogenicity
Additional Subjects Carcinogenesis ; Chlordane ; Malignant neoplasms ; Pesticides ; Toxicity ; Bioassay ; Laboratory animals ; Liver ; Exposure ; Epidemiology ; Chlorinated hydrocarbons ; Toxic substances ; Carcinogenesis ; Cancer ; CAS 57-74-9 ; CAS 76-44-8 ; CAS 1024-57-3 ; Heptachlor epoxide ; Heptachlor ; Occupational safety and health
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EHAM  RC268.64.C37C3 1986 Region 1 Library/Boston,MA 04/29/2016
EJED  EPA 600/6-87-004 OCSPP Chemical Library/Washington,DC 01/01/1988
EKBD  EPA-600/6-87-004 Research Triangle Park Library/RTP, NC 01/01/1988
EKCD  EPA/600/6-87/004 CEMM/GEMMD Library/Gulf Breeze,FL 07/25/2018
ELBD ARCHIVE EPA 600-6-87-004 Received from HQ AWBERC Library/Cincinnati,OH 10/04/2023 DISPERSAL
ERAD  EPA 600/6-87-004 Region 9 Library/San Francisco,CA 09/06/2013
ESAD  EPA 600-6-87-004 Region 10 Library/Seattle,WA 03/23/2010
NTIS  PB87-208757 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 1 volume (various pagings) : illustrations ; 28 cm
Evidence pertaining to the carcinogenicity of chlordane and heptachlor/heptachlor epoxide is reviewed and evaluated. The report covers studies completed before 1985. Case reports and epidemiologic studies of pesticide applicators and pesticide manufacturing workers are reviewed, but because of methodologic limitations, these studies establish neither a positive nor a negative association between cancer and chlordane or heptachlor/heptachlor epoxide exposure. A number of independent studies of laboratory animals, however, demonstrates that chlordane and heptachlor/heptachlor epoxide cause liver cancer in mice and rats. Based on the accumulated evidence, chlordane and heptachlor/heptachlor epoxide are classified as probable human carcinogens, Group B2 using EPA's Guidelines for Carcinogen Risk Assessment. The carcinogenic potency of chlordane and heptachlor/heptachlor epoxide is estimated by fitting mathematical models to the laboratory animal data. These estimates indicate that chlordane and heptachlor/heptachlor epoxide are rather potent carcinogens, ranking in the second quartile of potential carcinogens evaluated by EPA's Carcinogen Assessment Group. A separate mutagenicity assessment of chlordane and heptachlor/heptachlor epoxide is attached as an appendix to the report. The report also includes an extensive list of references pertinent to the carcinogenicity of chlordane and heptachlor/heptachlor epoxide.
Distributed to depository libraries in microfiche. "December 1986." Includes bibliographical references (pages 7-1-7-10). "EPA-600/6-87/004."