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Main Title Inhalation Development Toxicity Study in Mice with C-9 Aromatic Hydrocarbons (Draft) with Cover Letter dated 03/15/88.
CORP Author International Research and Development Corp., Mattawan, MI. ;American Petroleum Inst., Washington, DC.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Publisher 21 Mar 1988
Year Published 1988
Report Number FYI-AX-0388-0605;
Stock Number OTS-0000605-0
Additional Subjects Aromatic hydrocarbons ; Toxicity tests ; Inhalation ; Environmental exposure ; Health effects ; Mice ; Laboratory animals ; Maternal toxicity ; Fetal body weight ; Developmental defects ; Birth defects ; C9 Aromatic hydrocarbons
Library Call Number Additional Info Location Last
NTIS  OTS-0000605-0 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 212p
Mated Charles River CD(trademark)-1 female mice assigned to one control and three treatment groups of 30 animals each were used to determine the developmental toxicity potential of C(sub 9) Aromatic Hydrocarbons. Actual (measured) concentration levels of 100, 500, and 1,500 ppm were received by the animals through whole body inhalation exposure methods once daily for a 6-hour period. Exposure began on day 6 of gestation and was continued to, and included day 15 of gestation. The control group received filtered air on a comparable regimen. Cesarean sections were performed on all females on gestation day 18 and the fetuses were removed for teratologic evaluation. Exposure to the test article elicited developmental toxicity at the 500 and 1,500 ppm levels. Maternal toxicity was elicited at the 1,500 ppm level. In conclusion, the observable effect of C(sub 9) Aromatic Hydrocarbons with respect to toxicity was considered to be 100 ppm when administered by inhalation methods to Charles River CD-(trademark)-1 mice.