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Main Title Initial Submission: Subacute Inhalation Toxicity of Butyraldehyde in Rats, Mice, Guinea Pigs, Rabbits, and Dogs with Cover Letter dated 09/01/1992.
CORP Author Carnegie-Mellon Inst. of Research, Pittsburgh, PA.; Du Pont de Nemours (E.I.) and Co., Wilmington, DE.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1992
Report Number 8EHQ-0892-10075
Stock Number OTS0570659
Additional Subjects Toxicology ; Health effects ; Toxic substances ; Butyraldehyde ; Subchronic toxicity ; Mammals ; Rats ; Inhalation ; Mice ; Guinea pigs ; Rabbits ; Dogs ; CAS No 123-72-8
Library Call Number Additional Info Location Last
NTIS  OTS0570659 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 19p
Rats, mice, guinea pigs, rabbits and dogs were exposed to butyraldehyde vapor 6 hours/day, 5 days/week for 9 days over a two-week period. The measured concentrations for the 3 test levels were 6400, 3100 and 2000 ppm. Definite signs of eye and respiratory irritation, and statistically significantly lower body weight findings were observed in most species inhaling 6400 and 3100 ppm of butyraldehyde. Other signs observed in most animals at 6400 ppm included coordination loss, anesthesia and death. At 3100 ppm these effects were observed only in the beagle dog. Only some eye and respiratory irritation and statis- tically significantly lower body weight effects were observed among animals inhaling 2000 ppm of butyraldehyde. Scattered organ weight effects were found in rats for both test groups (3100 and 2000 ppm) surviving the 9-day inhalation treatment. (Further interpretation of these organ weight findings will probably be forthcoming in the following 13 week study.) No pathologically significant treatment related gross lesions were found among animals inhaling 3100 or 2000 ppm of butyraldehyde. One male Sprague-Dawley rat that had been exposed to 6400 ppm had bilateral bemorrhage of the ethmoturbinates.