Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Biological data for pharmacokinetic modeling and risk assessment : report of a workshop convened by the U.S. Environmental Protection Agency and ILSI Risk Science Institute.
CORP Author Eastern Research Group, Inc., Arlington, MA.;Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment.;American Industrial Health Council, Scarsdale, NY.;American Petroleum Inst., Washington, DC.;Mobil Oil Corp., New York.
Publisher U.S. Environmental Protection Agency,
Year Published 1989
Report Number EPA/600/3-90/019; OHEA/I-347
Stock Number PB90-212556
OCLC Number 21947281
Subjects Environmental protection--United States.
Additional Subjects United States.--Environmental Protection Agency. ; Toxicity ; Graphs(Charts) ; Methylene chloride ; Butadienes ; In vivo analysis ; In vitro analysis ; Benzene ; Liver ; Pharmacokinetics ; Risk assessment ; Dose-response relationships
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EHBD  EPA/600/3-90/019 CEMM/ACESD Library/Narragansett,RI 03/16/2007
EJBD ARCHIVE EPA-600-3-90-019 Headquarters Library/Washington,DC 04/14/2014
EJED  EPA-600/3-90/019 OCSPP Chemical Library/Washington,DC 02/22/1992
EKBD  EPA/600/3-90/019 Research Triangle Park Library/RTP, NC 06/29/1990
EKCD  EPA/600/3-90/019 CEMM/GEMMD Library/Gulf Breeze,FL 07/17/2018
EMBD  EPA/600/3-90/019 NRMRL/GWERD Library/Ada,OK 02/17/1995
ESAD  EPA 600-3-90-019 Region 10 Library/Seattle,WA 07/29/2005
NTIS  PB90-212556 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 01/01/1988
Collation 1 volume (various pagings)
The report summarizes the information presented at the 'Workshop on Biological Data for Pharmacokinetic Modeling and Risk Assessment' held by EPA and the Risk Science Institute on May 23-25, 1988, in Asheville, North Carolina. The report provides a general background of risk assessment and reviews how biological data are used in risk assessment and the ways pharmacokinetic modeling can reduce the uncertainties in risk assessment. Different biological models and their value are described, and the differences between predictive and descriptive models are explained. The report reviews the development and history of pharmacokinetic models, the strengths and limitations of the models, the types of biological data necessary to use pharmacokinetic models, and the role of sensitivity analysis in incorporating pharmacokinetic data into risk assessment. Hepatic metabolism data is used as an example of incorporating in vitro and in vivo data into pharmacokinetic models. Two approaches used for cross-species scaling are included, as well as biotransformation and the correlation of in vitro and in vivo data. Actual case studies showing pharmacokinetic modeling used in risk assessment are also described, and research needs are identified.
"EPA/600/3-90/019." "August 1989." "Office of Health and Environmental Assessment."