||On the Question of the Mode of Action of the Bronchosecretolytic Agent, N-Cyclohexyl-N-Methyl-(2-Amino-3, 5-Dibromobenzyl)-Ammonium Chloride.
Eigelsreiter, H. ;
Mair., M. ;
||National Institutes of Health, Bethesda, Md. Translation Unit.;Environmental Protection Agency, Research Triangle Park, N.C. Translation Services Section.
Muscle relaxants ;
Respiratory system ;
West Germany ;
||Some EPA libraries have a fiche copy filed under the call number shown.
Although it appears to be certain that N-Cyclohexyl-N-methyl-(2-amino-3, 5-dibromobenzy)-ammonium chloride (Bisolvon) has an expectoration-promoting effect in animals, and human beings, the mechanism of action has not been thoroughly elucidated. Beside the reduction of viscosity of the bronchial secretion and a considerable increase in the granula of the secretion and of lysosomes in the caliciform cells, there also exists a dispute over an increased absorption from the bronchial tract. In the present examination an experiment was undertaken for the purposes of further clarification of the mechanism of action of Bisolvon.