The paper discusses EPA's development of a technological program to implement in the U.S. the Montreal Protocol on Substances that Deplete the Ozone Layer. EPA's Office of Air and Radiation (OAR) has the lead for developing the technical and economic goals of the program, and EPA's Office of Research and Development (ORD) has the lead in providing technical support to meet the goals, including both short-term projects and long-term research. EPA's strategy is to target the halon and high chlorofluorocarbon (CFC)-using industries or industry subgroups to identify opportunities to reduce CFC and halon usage and find alternatives. When such opportunities are found, cooperative industry/government groups are formed to identify and solve the problems that impede transition away from CFC and halon usage. Other groups (including academic, non-profit research institutes, other government agencies, and foreign individuals or groups) are invited to join in the effort if they have a special expertise or interest. Identifying the high-use industry sectors and subsectors is not difficult; however, identifying appropriate industries, individuals, and groups who are willing to influence industry usage of CFCs is not easy.