| Main Title |
Methyl mercury and the metabolic responses of brain tissue / |
| Author |
Bull, Richard J.
|
| CORP Author |
Health Effects Research Lab., Cincinnati, Ohio. Water Quality Div. |
| Publisher |
U.S. Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratory ; Available through the National Technical Information Service, |
| Year Published |
1976 |
| Report Number |
EPA-600/1-76-013 |
| Stock Number |
PB-252 006 |
| OCLC Number |
02484094 |
| Subjects |
Mercury in the body ;
Mercury--Physiological effect ;
Brain ;
brains
|
| Additional Subjects |
Mercury organic compounds ;
Toxicity ;
Mercury poisoning ;
Nucleotides ;
Recommendations ;
Exposure ;
Rats ;
Responses ;
Growth ;
Metabolism ;
Water pollution ;
Laboratory animals ;
Experimental data ;
Neurology ;
Brain damage ;
Potable water ;
Physiological effects ;
Central nervous system ;
Ingestion(Biology) ;
Glycolysis ;
Mercury/chloro-methyl ;
Environmental health ;
Water pollution effects(Animals)
|
| Internet Access |
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| EJBD |
EPA 600-1-76-013 |
c.1 |
Headquarters Library/Washington,DC |
02/27/2014 |
| EKBD |
EPA-600/1-76-013 |
|
Research Triangle Park Library/RTP, NC |
06/06/2003 |
| ELBD ARCHIVE |
EPA-600-1-76-013 |
Received from HQ |
AWBERC Library/Cincinnati,OH |
10/04/2023 |
| ELBD |
EPA 600-1-76-013 |
|
AWBERC Library/Cincinnati,OH |
11/15/2016 |
| NTIS |
PB-252 006 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
vii, 24 pages : graphs ; 28 cm |
| Abstract |
Weanling, Sprague-Dawley rats have been exposed to methyl mercuric chloride (concentrations from 0.01 to 10.0 mg/liter) in their drinking water. At 10 mg/liter the animals exhibited neurological symptoms typical of methyl mercury. Also, in this group a considerable decrease in growth occurred which was associated with a decreased consumption of food. Responses of the respiratory intermediates to stimulation were found to be altered in cerebral cortex slices taken from exposed animals. Effects on tissue pyridine nucleotides predominated. An enhancement of the rate of pyridine nucleotide reduction by electrical stimulation was observed at 0.1 mg/liter. This rate progressively decreased at higher dose levels. Reoxidation of reduced pyridine nucleotide was also inhibited at 0.1 mg/liter at both 90 and 180 days of exposure. Potassium stimulated aerobic glycolysis was found to be enhanced in its initial stages at 0.10 mg/liter of methyl mercuric chloride in the drinking water but progressively declined at 1.0 and 10 mg/liter. |
| Notes |
Includes bibliographical references (pages 21-23). |
