| Main Title |
Electrophysiological Measures of Visual and Auditory Function as Indices of Neurotoxicity (Journal Version). |
| Author |
Otto, D. ;
Hudnell, K. ;
Boyes, W. ;
Janssen, R. ;
Dyer, R. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
| Publisher |
1988 |
| Year Published |
1988 |
| Report Number |
EPA/600/D-88/079; |
| Stock Number |
PB89-110415 |
| Additional Subjects |
Electrophysiology ;
Visual evoked potentials ;
Auditory evoked potentials ;
Toxicity ;
Nervous system ;
Humans ;
Laboratory animals ;
Brain stem ;
Reprints ;
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB89-110415 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
14p |
| Abstract |
The application of auditory and visual evoked potential (VEP) to neurotoxicity testing of humans and animals is reviewed. VEPs elicited by flash, reversing-checkerboard patterns, and sine wave grating are described. The flash evoked potential in rats is altered by exposure to many heavy metals, pesticides and solvents. The brainstem auditory evoked potential also appears to be sensitive to neurotoxic chemicals, but the evidence available is limited. The homology of auditory and visual evoked potentials in rats and humans is useful for cross-species extrapolation in neurotoxicology research. |
