Record Display for the EPA National Library Catalog


Main Title Comparison of Skull and Femur Lead Levels in Adult Rats.
Author Denton, J. E. ; Potter, G. D. ; Santolucito, J. A. ;
CORP Author Environmental Monitoring Systems Lab., Las Vegas, NV.
Year Published 1979
Report Number EPA-600/J-80-367;
Stock Number PB82-143272
Additional Subjects Lead(Metal) ; Toxicology ; Comparison ; Concentration(Composition) ; Skull ; Femur ; Bones ; Rats ; Reprints ; Bioaccumulation
Library Call Number Additional Info Location Last
NTIS  PB82-143272 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 8p
The purpose of the study was to elucidate the relationship between skull and femur lead levels in laboratory rats. Forty-eight female rats were given one of four lead chloride drinking water solutions: 0.05, 0.58, 17, or 352 ppm lead. Two animals from each group were sacrificed after 3, 6, 9, 12, 15, and 24 weeks of treatment. Both femurs and the frontal and parietal bones of the skull were removed from each animal and analyzed for lead concentration by atomic absorption spectroscopy. A significant accumulation of lead was observed in femurs and skull bones only from animals in the 352 ppm lead treatment group. The lead concentrations of the femurs were significantly higher than skull lead concentrations for all groups and this relationship was described using a linear regression equation.