| Main Title |
1-Chloromethylpyrene: A Reference Skin Sensitizer and Genotoxin. |
| Author |
Ashby, J. ;
Gallagher, J. E. ;
Kohan, M. ;
Tinwell, H. ;
Kimber., I. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;Institut de Recherches Scientifiques sur le Cancer, Villejuif (France). ;Imperial Chemical Industries Ltd., Alderley Park (England). Central Toxicology Lab. |
| Publisher |
c1990 |
| Year Published |
1990 |
| Report Number |
EPA/600/J-90/174; |
| Stock Number |
PB91-115782 |
| Additional Subjects |
Toxicology ;
Mutagens ;
Skin(Anatomy) ;
Sensitizing ;
Deoxyribonucleic acids ;
Carcinogens ;
Salmonella typhimurium ;
Deoxyribonucleic acids ;
Mice ;
Lymph nodes ;
Bone marrow ;
Reprints ;
1-chloromethylpyrene ;
Mutagenicity tests ;
Micronucleus test ;
Benzo(a)pyrene ;
Biotransformation ;
Contact dermatitis
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB91-115782 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
10p |
| Abstract |
1-Chloromethylpyrene has been evaluated as a model mutagen and toxin related to the ultimate electrophiles derived from BaP and 1-nitropyren. It was mutagenic to Salmonella (>100 picograms/plate) and exceptionally reactive to DNA when assessed by the postlabeling assay. 1-CMP was inactive in a mouse bone marrow micronucleus assay when administered by gavage probably due to hydroylis whose kinetics have been studied (half life 23 min at 37 C). However as expected it was a potent skin toxin as determined by its activity as a mitogen to mouse skin and its contact allergenicity, as determined using the local lymph node proliferative assay. It is concluded that 1-CMP will probably be a potent human skin carcinogen and contact allergen. (Copyright (c) 1990 Elsevier Science Publishers B.V. (Biomedical Division).) |
