Record Display for the EPA National Library Catalog

RECORD NUMBER: 18 OF 43

Main Title In Vivo Bone Marrow Cytogenetics Study of Santicizer 141 Plasticizer in the Rat HL-83-209(241-151) with Cover Letter and Cover Memo.
CORP Author Monsanto Co., St. Louis, MO.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1984
Report Number 878214652
Stock Number OTS-0206604
Additional Subjects Toxicity ; Plasticizers ; Health effects ; Genotoxicity ; Chromosomal effects ; Mammals ; Rats ; Laboratory animals ; Oral ; Gavage ; Chromosome abberations ; Frequencies ; Dosages ; 2-ethylhexyl diphenyl phosphate ; Aryl phosphates ; CAS No 1241-94-7 ; Bone marrow cells ; Monsanto Corporation
Holdings
Library Call Number Additional Info Location Last
Modified		 Checkout
Status
NTIS  OTS-0206604 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 70p
Abstract
The frequency of chromosome aberrations was determined in the bone marrow cells of Sprague-Dawley rats exposed by oral gavage to a single dose of 2-ethylhexyl diphenyl phosphate. Forty eight animals per group (24 male and 24 female) received dosages of 0, 1500, 5000 and 15000 mg/kg test article in corn oil. Statistically significant (KW-ANOVA, p < 0.05) differences in the percent aberrant cells, mean number of aberrations per cell, mean mitotic index, or mean modal number were not observed at any dose level. The dose levels were chosen based on the results of a preliminary range finding study and the previously determined LD50. Clinical observations of dose related toxicity during the test included soft feces, urine stains, depression, rough coat, red stains on nose and eyes, hunching and decreased body weights. Additionally, mortality was observed in five animals in the mid dose group.