| Main Title |
Utility of activity and observational data for neurotoxicity screening / |
| Author |
Moser, Virginia C.
|
| Other Authors |
|
| CORP Author |
ManTech Environmental Technology, Inc., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC. |
| Publisher |
U.S. Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratory, |
| Year Published |
1992 |
| Report Number |
EPA/600/A-92/194; EPA-68-02-4450 |
| Stock Number |
PB92-232826 |
| Additional Subjects |
Toxicity ;
Nervous system ;
Tests ;
Body weight ;
Animal behavior
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB92-232826 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
17 pages ; 28 cm |
| Abstract |
Observational and activity tests provide neurobehavioral data critical for assessing a chemical's effects on the nervous system. The measures are sensitive, relatively specific, and provide information about the effects of the chemical in specified functional domains. These measures are also valuable additions to mechanistic studies, although not specifically designed for this purpose. Furthermore, they are sufficiently sensitive that conservative exposure standards could be determined in the absence of additional neurotoxicity data. There are numerous advantages to including these tests in acute, subchronic, or chronic studies. The measures are quite reliable over time, and given the additional benefits of collecting neurobehavioral data, there is good reason to include these assessments in standard toxicity tests. |
| Notes |
Includes bibliographical references. "EPA/600/A-92/194"--Cover. "Running title: Screening for Neurotoxicity." Microfiche. |
