Record Display for the EPA National Library Catalog
RECORD NUMBER: 11 OF 19Main Title | Multicompartment Kinetic Model for Lead. Part 3. Lead in Blood Plasma and Erythrocytes. | |||||||||||
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Author | Marcus, A. H. ; | |||||||||||
CORP Author | Washington State Univ., Pullman. Dept. of Pure and Applied Mathematics.;Health Effects Research Lab., Research Triangle Park, NC. | |||||||||||
Year Published | 1985 | |||||||||||
Report Number | EPA/600/J-85/362; | |||||||||||
Stock Number | PB86-177698 | |||||||||||
Additional Subjects | Lead(Metal) ; Blood plasma ; Mathematical models ; Concentration(Composition) ; Erythrocytes ; Reprints ; Kinetic models | |||||||||||
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Collation | 19p | |||||||||||
Abstract | Multicompartment models have been fitted to experimental data on plasma lead and blood lead concentrations of subjects studied by de Silva (1981, Brit. J. Industr. Med. 38, 209-217) and one subject studied by Manton and Malloy (1983, Brit. J. Industr. Med., 40, 51-57). Nonlinear models for plasma lead vs. blood lead in populations provide significantly better descriptions than does a linear model. Short-term kinetic data do not clearly resolve the precise nonlinear mechanism, however. Parameters of plasma and erythrocyte distribution in a single subject were significantly different on two occasions. |