| Main Title |
Evaluation of the Dorset Sheep as a Predictive Animal Model for the Response of G-6-PD Deficient Human Erythrocytes to a Proposed Systemic Toxic Ozone Intermediate, Methyl Oleate Hydroperoxide. |
| Author |
Calabrese, E. J. ;
Moore, G. S. ;
Williams, P. S. ;
|
| CORP Author |
Massachusetts Univ., Amherst. Dept. of Public Health.;Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1983 |
| Report Number |
EPA/600/J-83/289; |
| Stock Number |
PB85-193753 |
| Additional Subjects |
Ozone ;
Toxicology ;
Erythrocytes ;
Humans ;
Sheep ;
Blood cells ;
Reprints ;
Oleic acid/hydroperoxyl-methyl ;
Animal models
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB85-193753 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
7p |
| Abstract |
Erythrocytes of both G-6-PD deficient humans and Dorset sheep, an animal model with an erythrocyte G-6-PD deficiency, both responded in a dose dependent manner to the oxidant stress of MOHP as measured by decreases in G-6-PD activity, increases in METHB levels and decreases in GSH. However, the human G-6-PD deficient erythrocytes were considerably more sensitive to the formation of METHB than the sheep erythrocytes while the reverse was the case for the GSH parameter. The results suggest a qualitative difference in the response of sheep erythrocytes and human G-6-PD deficient erythrocytes to MOHP that seriously questions the value of the sheep erythrocytes as a quantitatively accurate predictive model. |
