Record Display for the EPA National Library Catalog


Main Title Polar Narcosis in Aquatic Organisms.
Author Bradbury, S. P. ; Carlson, R. W. ; Henry, T. R. ;
CORP Author Environmental Research Lab., Duluth, MN. ;American Scientific International, Duluth, MN.
Publisher c1989
Year Published 1989
Report Number EPA/600/D-89/177;
Stock Number PB90-116062
Additional Subjects Aquatic biology ; Polarity ; Narcosis ; Blood chemical analysis ; Respiration ; Blood circulation ; Reprints ; Water pollution effects(Animals) ; Toxic substances ; Structure-activity relationship ; Synergism
Library Call Number Additional Info Location Last
NTIS  PB90-116062 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 18p
The majority of industrial organic chemicals lack identifiable structural characteristics that result in specific biological activity. These nonpolar-nonelectrolytes are acutely toxic to aquatic organisms via a nonspecific mode of action termed narcosis. The toxicity of industrial chemicals eliciting nonpolar narcosis can be reliably predicted by log P (baseline toxicity models). Using single chemical and joint toxic action models, several research groups have reported classes of polar compounds (for example, esters, phenols, and anilines) that elicit a narcosis-like syndrome; however, they are more acutely toxic than what is predicted using baseline toxicity models. An assessment of rainbow trout (Salmo gairdneri) in vivo respiratory-cardiovascular responses during intoxication by polar narcotic phenol and aniline derivatives established a toxicity syndrome unique to that elicited by nonpolar narcotics. The finding further suggests a mode of action unique to polar narcotics and supports the use of structure-activity relationships specific for these compounds. (Copyright (c) American Society for Testing and Materials.)