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Main Title Effects of pesticides on the immune response /
Author Dandliker, Walter B.
Other Authors
Author Title of a Work
Dandliker, Walter B.
CORP Author Scripps Clinic and Research Foundation, La Jolla, CA. Dept. of Biochemistry.;Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div.
Publisher Health Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Available through the National Technical Information Service.
Year Published 1979
Report Number EPA-600/1-79-039; EPA-R-803885
Stock Number PB80-130834
OCLC Number 20957383
Subjects Pesticides--Health aspects ; Pesticides--adverse effects ; Immune System--drug effects
Additional Subjects Pesticides ; Immunology ; Ingestion(Biology) ; Histology ; Temperature ; Chlorine organic compound ; Insecticides ; Parathion ; Immune responses ; Aroclor 1260 ; Biphenyl/hexachloro ; Dinoseb ; Phenol/buty-dinitro ; PCNB fungicide ; Benzene/nitro-pentachloro ; Pyrethrins ; Resmethrin ; Butoxide/piperonyl
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EJBD  EPA 600-1-79-039 c.1 Headquarters Library/Washington,DC 04/28/2014
EKBD  EPA-600/1-79-039 Research Triangle Park Library/RTP, NC 06/01/2001
ELBD ARCHIVE EPA 600-1-79-039 Received from HQ AWBERC Library/Cincinnati,OH 10/04/2023
ELBD  EPA 600-1-79-039 AWBERC Library/Cincinnati,OH 06/29/2021
NTIS  PB80-130834 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation v, 44 pages : illustrations ; 28 cm
The influence of various pesticides on the humoral and cellular immune response to fluorescein labeled ovalbumin has been analyzed. Pesticides (Aroclor 1260, Dinoseb, Parathion, pentachloronitrobenzene, piperonyl butoxide, mixed pyrethrins and Resmethrin) were administered intragastrically in corn oil in one dose (one half of LD50) before primary immunization. Control groups included those treated with corn oil alone or immunosuppressed with Methotrexate. Booster immunizations and test bleedings were scheduled at weekly intervals thereafter. The cellular immune response was quantified by redness and swelling, histological examination and by differential temperature measurements of the foot pads after antigen challenge. The concentration, binding affinity and heterogeneity of the serum antibody were determined by fluoroscience polarization measurements. Dinoseb and Parathion depress both the humoral and cellular response. Methotrexate and pentachloronitrobenzene give a late stimulation, while Resmethrin an early, sometimes very marked stimulation of the cellular immune response. Other pesticides showed little or no effect under the conditions tested. Effects on the humoral response were limited to changes in antibody concentration, the binding affinity being nearly constant in all instances.
"EPA-600/1-79-039." September 1979.