Record Display for the EPA National Library Catalog


Main Title Toxicological Assessment of Hexachloroniphenyl Isomers and 2,3,7,8-Tetrachlorodibenzofuran in Chicks. II. Effects on Drug Metabolism and Porphyrin Accumulation.
Author Goldstein, Joyce A. ; McKinney, James D. ; Lucier, George W. ; Hickman, Patricia ; Bergman., Hinda ;
CORP Author National Environmental Research Center, Research Triangle Park, N. C. ;National Inst. of Environmental Health Sciences, Research Triangle Park, N.C.
Year Published 1975
Stock Number PB-279 178
Additional Subjects Toxicology ; Pesticides ; Metabolism ; Chlorine organic compounds ; Furans ; Chickens ; Laboratory animals ; Experimental data ; Tables(Data) ; Physiological effects ; Drugs ; Porphyrins ; Liver ; Cytochromes ; Tissues(Biology) ; Enzymes ; Body weight ; Biphenyl/hexachloro ; Reprints ; Furan/dibenzo-tetrachloro ; Polychlorinated biphenyls ; Toxic substances ; Bioaccumulation
Library Call Number Additional Info Location Last
NTIS  PB-279 178 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 12p
Pure hexachlorobiphenyl (HCB) isomers induce a number of changes in parameters of drug metabolism in the chick including changes in cytochrome P-450, liver weight, and p-nitrophenol glucuronyl transferase, but not in testosterone glucuronyl transferase activity. The most active inducers of drug metabolism were 2,3,4,2',3',4'-HCB and 2,4,6,2',4',6'-HCB, while 2,4,5,2',4',5'-HCB produced intermediate effects and 2,3,6,2'.3',6'-HCB was a poor inducer. All HCBs caused uroporphyrin accumulation and increased delta-aminolevulinic acid (ALA) synthetase activity, but only 3,4,5,3',4',5'-HCB, 2,3,4,2',3',4'-HCB, and 2,4,5,2',4',5'-HCB produced gross accumulation of hepatic porphyrins. Tissue HCB concentrations correlated well with hepatic effecs. 2,3,7,8,-Tetrachlorodibenzofuran (TCDF), a contaminant of commercial polychlorinated biphenyl (PCB) mixtures, had no effects on hepatic ALA synthetase activity, porphyrin accumulation, or glucuronyl transferase. TCDF did produce a slight increase in cytochrome P-450, but the increase was smaller than that produced by HCBs.