Mechanosensitive Channels -- Experimental Methods of Studying Mechanosensitive Channels and Possible Errors in Data Interpretation -- Role of Lipid Bilayer Mechanics in Mechanosensation -- Mechanosensitive Channels Gated by Membrane Tension -- Computational Studies of the Bacterial Mechanosensitive Channels -- Mechanosensory Transduction in the Nematode Caenorhabditis elegans -- Mechanosensitive Ion Channels in Odontoblasts -- Potassium Ion Channels in Articular Chondrocytes -- Osmotransduction Through Volume-Sensitive Cl- Channels -- Mechanosensitive Channel TRPV4 -- Mechanosensitive Signalling Cascades -- Mechanosensitive Purinergic Calcium Signalling in Articular Chondrocytes -- Signal Transduction Pathways Involved in Mechanotransduction in Osteoblastic and Mesenchymal Stem Cells -- Caveolae -- Multimodal Activation and Regulation of Neuronal Mechanosensitive Cation Channels -- Regulation of Intracellular Signal Transduction Pathways by Mechanosensitive Ion Channels -- Cell Mechanobiology -- The Effects of Mechanical Stimulation on Vertebrate Hearts -- Mechanobiology of Fibroblasts. Mechanosensitivity in Cells and Tissues as an Overall Regulatory System Kamkin and Kiseleva's assembly of leaders in the mechanosensitivity eld provides an excellent broad based and up-to-date book, with chapters in the rst part d- cussing mechanically gated channels (mechanogated), mechanosensitive channels (MGC,MSC) systems(asthe editorsair thenomenclatureintheireditorial),thes- ond describing their signaling, and the third presenting aspects of cell mechanobi- ogy. Conceptually starting with tension at the surface membrane, the book's theme movesonto somemolecularmechanisms,andthenonto MSC as initiatingcomplex cell signal cascades, sometimes invoking signalsomes. Mechanosensitivity is also described in organs. Mechanosensitivitydoes not only relate to very soft deformabletissue, but ch- ters also focuses on cells and tissues concerned essentially with skeletal growth and development. The state of the art covered in the book heralds, to me, a slant to mechanosensitivity in general. Galileo remarked in 1638 that longer bones were thicker for a given structural strength (Galilei, 1638) (translation in (Crewew & da Silavio, 1939)), and this was followed in 1859 by Darwin's noting that ying ducks have underdevelopedlegs as compared with terrestrial bound ones (Darwin, 1859).